Author(s): Teasdale ME, Shearer TL, Engel S, Alexander TS, Fairchild CR,
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Abstract Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
This article was published in J Org Chem
and referenced in Journal of Molecular and Genetic Medicine