alexa Building a tree of knowledge: analysis of bitter molecules.
Medicine

Medicine

Drug Designing: Open Access

Author(s): Rodgers S, Busch J, Peters H, ChristHazelhof E, Rodgers S, Busch J, Peters H, ChristHazelhof E

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Abstract A phylogenetic-like tree of structural fragments has been constructed to extract useful insights from a structural database of bitter molecules. The tree of structural fragments summarizes the substructural groups present in the molecules from the bitter database. These structural fragments are compared with a large number of random molecules to highlight substructures specific to bitter molecules. This organization of the structures enabled the detection of structure-activity relationships for the bitter molecules through the construction of R-tables. Key structural groups, able to distinguish between bitter and random molecules, were identified through an analysis of the tree. This information can be used to further understand which structural components are involved in producing a bitter taste. This article was published in Chem Senses and referenced in Drug Designing: Open Access

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