alexa Ca2+-ATPase activity in the human lens.


Journal of Clinical & Experimental Ophthalmology

Author(s): Borchman D, Paterson CA, Delamere NA

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Abstract A membrane-rich preparation of paired human lenses was prepared in such a manner as to preserve ATPase activity. The lipid:protein ratio of these preparations was increased 12-fold with an 85\% recovery of total phospholipid. The pattern of stimulation of ATPase activity by a range of calcium concentrations was found to be similar in membrane preparations of epithelium and cortex. The concentration of calcium necessary for half-maximal simulations of ATPase activity was approximately 10(-6) M. Ca2+-ATPase activity is undetectable in the lens nuclear region. A shift in the sensitivity of lens epithelial Ca2+-ATPase activity was observed with increasing age concomitant with a general increase in Ca2+-ATPase activity suggesting age related modifications of the membrane.
This article was published in Curr Eye Res and referenced in Journal of Clinical & Experimental Ophthalmology

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