alexa Cadmium retention increase: a probable key mechanism of the protective effect of zinc on cadmium-induced toxicity in the kidney.


Biochemistry & Physiology: Open Access

Author(s): Jihen el H, Fatima H, Nouha A, Baati T, Imed M,

Abstract Share this page

Abstract Zinc (Zn) reverses cadmium (Cd)-induced toxicity in kidneys although it increases Cd tissue burden, hence, the present study is designed to study the relationships between Cd, Zn and antioxidants in the kidneys of rats exposed to Cd orally. Male rats received either tap water, Cd or Cd+Zn in their drinking water during five weeks. Cd-induced increase in Cd and Zn accumulation was accompanied by a decrease in important variables (GSH, GSH/GSSG, CuZn SOD and GPx activities) and by an increase in others (Cd/Zn, GSSG and CuZn SOD/GPx). Zn supply intensified Cd retention and Cd/Zn; it amplified CuZn SOD activity, CuZn SOD/GPx and GSH/GSSG compared to normal values, but had no effect on Zn content increase. Besides, it ameliorated GPx activity and corrected GSSG level. High positive correlations were found between Cd concentrations and the majority of the studied variables suggesting a direct influence of Cd on them. Zn concentration had positive correlation with CuZn SOD/GPx, and negative one with GPx activity, which reflects an indirect protective effect of Zn. In conclusion, our results suggest that Zn increases Cd tissue retention in the kidney and that is probably the key mechanism of the protective effect of Zn. This article was published in Toxicol Lett and referenced in Biochemistry & Physiology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  •  2nd International Conference on Biochemistry
    Sep 21-22, 2017, Macau, Hong Kong
  • 2nd International Conference on Biochemistry
    September 28-29, 2017 Dubai, UAE

  • 3rd Annual Congress on Bioscience
    October 16-17, 2017 Dubai,UAE

  • 3rd International Conference on Transcriptomics
    October 30 - November 01, 2017 Bangkok, Thailand

  • 3rd International Conference on Genetic and Protein Engineering (10 Plenary Forums - 1 Event)
    November 08-09, 2017 Las Vegas, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

e[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version