alexa Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study.
Surgery

Surgery

Reconstructive Surgery & Anaplastology

Author(s): de Lange J, van den Akker HP, Veldhuijzen van Zanten GO, Engelshove HA, van den Berg H,

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Abstract The successful therapeutic use of calcitonin in patients with a central giant cell granuloma has been shown in several case reports. In a prospective, randomized, double-blinded, placebo-controlled clinical trial, 14 patients with a histologically confirmed central giant cell granuloma and normal calcium and parathyroid hormone serum levels were studied over 2 years. Patients were treated with intranasally administered salmon calcitonin (200 IU/day) or a placebo once a day. The placebo-controlled period was 3 months, after which all patients were treated with calcitonin for 1 year. Treatment response was assessed at the end of the placebo-controlled study phase (3 months), at the end of therapy (15 months' timepoint with patients being on calcitonin treatment for either 12 or 15 months) and at 6 months' follow-up. The chi(2)-test was used to compare the proportion of patients with a tumour reduction >/=10\% of the pretreatment measurement between the 2 populations at the 3 timepoints: no differences were observed between the placebo group and the calcitonin group. At the 6-month follow-up timepoint, tumour volume had decreased by >/=10\% in a total of 7 patients with a 37.9\% (95\% CI 31.3-44.5\%) mean volume reduction in this subgroup. Complete remission was not observed. This article was published in Int J Oral Maxillofac Surg and referenced in Reconstructive Surgery & Anaplastology

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