alexa Calcium antagonists inhibit elevated potassium efflux from aorta of aldosterone-salt hypertensive rats.
Cardiology

Cardiology

Journal of Hypertension: Open Access

Author(s): Smith JM, Jones AW

Abstract Share this page

Abstract The purpose of this study was to evaluate the effect of calcium antagonists on basal tension and the elevated 42K efflux in aorta from aldosterone-salt hypertensive rats. Diltiazem decreased the basal tension (2.0 +/- 0.4 g) as well as the phasic contractile activity and returned the elevated 42K efflux (0.018 +/- 0.002/min) toward control values (0.010 +/- 0.001/min, p less than 0.001). The diltiazem median inhibitory concentration (IC50) for basal tension (0.04 +/- 0.02 microM), however, was sevenfold less than the IC50 for basal 42K efflux (0.22 +/- 0.08 microM, p less than 0.01). The basal 45Ca influx in aorta from aldosterone-salt hypertensive rats (120 +/- 4 microM/l cell H2O/min) was also decreased by diltiazem in a concentration-dependent manner, whereas the 45Ca influx in aorta from control-salt rats (135 +/- 3 microM/l cell H2O/min) was not altered. Similarly, the dihydropyridine nisoldipine eliminated the basal tension (2.7 +/- 0.5 g) and returned the elevated basal 42K efflux from the hypertensive aorta toward control levels (0.010 +/- 0.0003/min, p less than 0.001). The nisoldipine IC50 for basal tension (0.016 +/- 0.01 nM) was 160-fold less than the IC50 for basal 42K efflux (1.8 +/- 1.2 nm, p less than 0.001). Neither diltiazem nor nisoldipine nisoldipine altered the basal 42K efflux or contractile activity of aorta from control-salt rats. These results suggest that the basal tension and elevated 42K efflux in aorta from aldosterone-salt hypertensive rats are supported by the entry of extracellular calcium into the tissue through potential-operated calcium channels.
This article was published in Hypertension and referenced in Journal of Hypertension: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords