alexa Calcium gradients underlying polarization and chemotaxis of eosinophils.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Brundage RA, Fogarty KE, Tuft RA, Fay FS

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The concentration of intracellular free calcium ([Ca2+]i) in polarized eosinophils was imaged during chemotaxis by monitoring fluorescence of the calcium-sensitive dye Fura-2 with a modified digital imaging microscope. Chemotactic stimuli caused [Ca2+]i to increase in a nonuniform manner that was related to cell activity. In cells moving persistently in one direction, [Ca2+]i was highest at the rear and lowest at the front of the cell. Before cells turned, [Ca2+]i transiently increased. The region of the cell that became the new leading edge had the lowest [Ca2+]i. These changes in [Ca2+]i provide a basis for understanding the organization and local activity of cytoskeletal proteins thought to underlie the directed migration of many cells.

This article was published in Science and referenced in Journal of Carcinogenesis & Mutagenesis

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