alexa Calcium signaling through CatSper channels in mammalian fertilization.


Journal of Microbial & Biochemical Technology

Author(s): Ren D, Xia J

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Abstract The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought. This article was published in Physiology (Bethesda) and referenced in Journal of Microbial & Biochemical Technology

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