Author(s): Savignac M, Mellstrm B, Naranjo JR
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Abstract The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
This article was published in Pflugers Arch
and referenced in Journal of Clinical & Cellular Immunology