Author(s): Maiese WM, Lechevalier MP, Lechevalier HA, Korshalla J, Kuck N,
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Abstract A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.
This article was published in J Antibiot (Tokyo)
and referenced in International Journal of Advance Innovations, Thoughts & Ideas