alexa Can vitamin D delay the progression of ALS?
Neurology

Neurology

Journal of Alzheimers Disease & Parkinsonism

Author(s): Karam C, Scelsa SN

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Abstract The pathogenesis of amyotrophic lateral sclerosis (ALS) is multifactorial and a treatment targeting only one aspect of the disease is unlikely to be beneficial. Vitamin D is safe and may delay progression of ALS by acting on several aspects of the disease. In this article we explore how vitamin D may promote VGEF, IGF-1 and axonal regeneration delaying ALS progression. In addition, we discuss how vitamin D may increase calcium binding protein in motor neuron cells conferring a greater resistance to the underlying disease process, as seen in the oculomotor nerve and Onuf's nucleus. Finally, we discuss vitamin D immunomodulator role, decreasing the reactive gliosis in ALS. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Med Hypotheses and referenced in Journal of Alzheimers Disease & Parkinsonism

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