Author(s): Anisimov VN, Ukraintseva SV, Yashin AI
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Abstract Information obtained from animal models (mostly mice and rats) has contributed substantially to the development of treatments for human cancers. However, important interspecies differences have to be taken into account when considering the mechanisms of cancer development and extrapolating the results from mice to humans. Comparative studies of cancer in humans and animal models mostly focus on genetic factors. This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature.
This article was published in Nat Rev Cancer
and referenced in Journal of Clinical Research & Bioethics