alexa Carbon paste electrode modified with copper (II) phosphate immobilized in a polyester resin for voltammetric determination of L-ascorbic acid in pharmaceutical formulations.
Engineering

Engineering

Journal of Biosensors & Bioelectronics

Author(s): Teixeira MF, Ramos LA, FatibelloFilho O, Cavalheiro ET

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Abstract A carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin (CuP-Poly) is proposed for voltammetric determination of L-ascorbic acid in pharmaceutical formulations. The modified electrode allows the detection of L-ascorbic acid at lower anodic potentials than observed at unmodified electrodes. Several parameters that can influence the voltammetric response of the proposed electrode such as carbon paste composition, pH, scan rate, and possible interference were investigated. The peak current was proportional to the concentration of ascorbic acid in the range 2.0 x 10(-5) to 3.2 x 10(-3) mol L(-1) with a detection limit of 1.0 x 10(-5) mol L(-1). The stability and repeatability of the electrode for the determination of L-ascorbic acid are also discussed. Amperometric response was also recorded for electrocatalytic oxidation of the L-ascorbic acid. Concentrations of the vitamin C in pharmaceutical formulations (tablets) measured using the modified electrode and a titrimetric method are in agreement at the 95\% confidence level and within an acceptable range of error. This article was published in Anal Bioanal Chem and referenced in Journal of Biosensors & Bioelectronics

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