alexa Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Perna FM, LaPerriere A, Klimas N, Ironson G, Perry A,

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Abstract PURPOSE: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. METHODS: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. RESULTS: Approximately 61\% of exercise-assigned participants complied (> 50\% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (VO2peak; 12\%), oxygen pulse (O2pulse; 13\%), tidal volume (TV; 8\%), ventilation (VE; 17\%), and leg power (25\%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18\%) significantly, whereas compliant exercisers' cell counts significantly increased (13\%; P < 0.05). CONCLUSION: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.
This article was published in Med Sci Sports Exerc and referenced in Journal of AIDS & Clinical Research

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