alexa CART peptides are modulators of mesolimbic dopamine and psychostimulants.


Journal of Addiction Research & Therapy

Author(s): Jaworski JN, Vicentic A, Hunter RG, Kimmel HL, Kuhar MJ

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Abstract CART peptide produces behavioral effects when injected into the VTA or nucleus accumbens. In the VTA, the peptide behaves like an endogenous psychostimulant and produces increased locomotor activity and conditioned place preference. Since this is blocked by dopamine receptor blockers, it presumably involves release of dopamine. But in the nucleus accumbens, CART peptide reduces the locomotor-increasing effects of cocaine. This suggests that the peptide is an interesting target for medications development.
This article was published in Life Sci and referenced in Journal of Addiction Research & Therapy

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