Author(s): Villa P, Kaufmann SH, Earnshaw WC
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Abstract Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.
This article was published in Trends Biochem Sci
and referenced in Journal of Nephrology & Therapeutics