alexa Cathepsin-D, adiponectin, TNF-α, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: a multicentric study.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Ahmad J, Zubair M, Malik A, Siddiqui MA, Wangnoo SK

Abstract Share this page

Abstract Diabetic foot, characterized by a pronounced inflammatory reaction, decreased collagen content and biosynthesis and accelerated degradation are crucial in wound healing. Cathepsin D, an aspartic endopeptidases implicated in cell growth, apoptosis, and its inhibitor has been reported to reverse the inhibition of collagen biosynthesis in wounded rat skin with diabetes. To date, the increased proteolytic activity of Cathepsin D in diabetic foot has not been evaluated and the pathogenic significance of the inflammation has received little attention. Of the patients [with ulcer (n=211) and without ulcer (n=208)], 89.73\% had type 2 diabetes. Subjects with diabetic foot ulcer showed higher median plasma level of Cathepsin D [556.3 (312.6-587.3) RFC/ml vs 306.3 (92.6-337.3) RFC/ml], TNF-α [96.6 (79.9-121.5) ng/ml vs 8.4 (7.1-9.20) ng/ml], IL-6 [32.2 (8.52-48.4) ng/ml vs 4.9 (4.5-5.6) ng/ml], hsCRP [12.6 (11.2-14.1) mg/ml vs 3.90 (3.50-4.60) mg/ml] and lower median plasma levels of adiponectin [8.50 (7.10-9.5) ng/ml vs 13.3 (12.1-14.2) ng/ml]. A positive correlation was found between grades of ulcer, BMI, A1c and retinopathy for Cathepsin D, for adiponectin, between grades of ulcer, BMI, retinopathy, nephropathy & smoking, for IL-6, between grades of ulcer, BMI, nephropathy, CAD & smoking, for hsCRP, grades of ulcer, BMI, LDL-C, nephropathy & smoking, while total cholesterol, nephropathy, PAD, smoking and neuropathy for TNF-α. Copyright © 2012 Elsevier Ltd. All rights reserved. This article was published in Foot (Edinb) and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords