alexa Caveolin, caveolae, and endothelial cell function.

Journal of Autacoids and Hormones

Author(s): Frank PG, Woodman SE, Park DS, Lisanti MP

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Abstract Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease. This article was published in Arterioscler Thromb Vasc Biol and referenced in Journal of Autacoids and Hormones

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