alexa Cbl: many adaptations to regulate protein tyrosine kinases
Immunology

Immunology

Immunome Research

Author(s): Thien CB, Langdon WY

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Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

This article was published in Nat Rev Mol Cell Biol and referenced in Immunome Research

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