Author(s): Maue AC, Haynes L
Abstract Share this page
Abstract Age-related declines in immune function are associated with reduced humoral responses following vaccination or infection. Central to this defect is a decline in naïve CD4+ T cell function. In this review, we discuss factors intrinsic and extrinsic to the CD4+ T cell compartment that affect host immunity and propose means by which deficient CD4+ T cell function can be fully restored in the aged. Copyright 2009 S. Karger AG, Basel.
This article was published in Gerontology
and referenced in Journal of Gerontology & Geriatric Research