Persons using assistive technology might not be able to fully access information in this file. For assistance, please send e-mail to: [email protected] Type 508 Accommodation and the title of the report in the subject line of e-mail. Notice to Readers: CDC's Campaign to Prevent Antimicrobial Resistance in Health-Care Settings Each year, approximately 2 million U.S. patients acquire an infection while hospitalized; approximately 90,000 of these infections are fatal. Many more infections are acquired in nursing homes and other health-care facilities in which vulnerable patients receive care. Guidelines for preventing antimicrobial-resistant infections in health-care settings exist; however, these guidelines often are not read by clinicians and adherence is not optimal. Most data indicate that guidelines alone are not effective in preventing antimicrobial resistance. New approaches are needed to help clinicians who treat patients with infections translate these guidelines into routine practice behaviors that will prevent antimicrobial resistance. In response to this issue, CDC has initiated the "Campaign to Prevent Antimicrobial Resistance." The campaign focuses on four integrated strategies: preventing infection, diagnosing and treating infection effectively, using antimicrobials wisely, and preventing transmission. The campaign is designed to highlight the importance of antimicrobial resistance and engage clinicians, health-care facilities, and patients in efforts to prevent resistance and promote safer care. The first major new tool is the "12 Steps to Prevent Antimicrobial Resistance: Hospitalized Adults." These steps were derived by translating existing evidence-based guidelines and recommendations into action steps that will help change practices and prevent resistance. The 12 Steps will be marketed through slide sets, web presentations, posters, pocket cards, and other media. Plans are in progress to create similar tools that target other patient groups and their clinicians, including pediatricians, surgeons, critical-care specialists, geriatricians, emergency physicians, obstetricians, and family practitioners.