Author(s): Cukierman E, Pankov R, Yamada KM
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Abstract Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.
This article was published in Curr Opin Cell Biol
and referenced in Journal of Bioengineering & Biomedical Science