alexa Cellular microparticles: a disseminated storage pool of bioactive vascular effectors.
Cardiology

Cardiology

Atherosclerosis: Open Access

Author(s): Morel O, Toti F, Hugel B, Freyssinet JM

Abstract Share this page

Abstract PURPOSE OF REVIEW: Microparticles (MP) or microvesicles are fragments shed from the plasma membrane of stimulated or apoptotic cells. Having long been considered inert debris reflecting cellular activation or damage, MP are now acknowledged as cellular effectors involved in cell-cell crosstalk. This review focuses on procoagulant MP circulating in the vascular compartment, their role in hemostasis and thrombosis, and possible impact in vascular functions. RECENT FINDINGS: Microparticles can be viewed as a "storage pool" by themselves, disseminating blood-borne tissue factor activity and procoagulant phospholipids. Increasing evidences of integrated loops involving dynamic exchanges and transfer events through multiple MP-cell interactions are summarized. SUMMARY: Microparticles can be considered true targets in the pharmacological control of thrombosis. Another challenging issue is to take advantage of their procoagulant potential for the management of hemophilia.
This article was published in Curr Opin Hematol and referenced in Atherosclerosis: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords