alexa Cellulose acetate butyrate and polycaprolactone for ketoprofen spray-dried microsphere preparation.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Giunchedi P, Conti B, Maggi L, Conte U

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Abstract Ketoprofen-loaded microspheres made with a polymeric blend were prepared by a spray-drying technique. Organic solutions of two polymers, cellulose acetate butyrate (CAB) and poly(epsilon-caprolactone) (PCL), in different weight ratios, and of ketoprofen (Ket) were prepared and sprayed, in different experimental conditions, achieving drug-loaded microspheres. The obtained spray-dried microspheres were characterized in terms of yield of production, shape, size, surface properties and drug content, and their in vitro drug release behaviours were determined at different pH values. This article was published in J Microencapsul and referenced in Pharmaceutica Analytica Acta

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