Author(s): Heinrich M, Wickel M, WinotoMorbach S, SchneiderBrachert W, Weber T,
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Abstract We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMase deficient cells derived from Niemann-Pick patients show decreased CTSD activity that was reconstituted by transfection with A-SMase cDNA. Ceramide accumulation in cells derived from A-ceramidase defective Farber patients correlates with enhanced CTSD activity. These findings suggest that A-SMase-derived ceramide targets endolysosomal CTSD.
This article was published in Adv Exp Med Biol
and referenced in Journal of Alzheimers Disease & Parkinsonism