Author(s): Hannun YA, Luberto C
Abstract Share this page
Abstract Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.
This article was published in Trends Cell Biol
and referenced in Biochemistry & Pharmacology: Open Access