alexa Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Clemens JA

Abstract Share this page

Abstract A large number of gene products appear after an ischemic insult making it difficult to decipher which genes are involved in tissue injury. Reactive oxygen species (ROS) can influence gene expression and have a role in the events that lead to neuronal death. In global cerebral ischemia the oxidative responsive transcription factor, NF-kappa B, is persistently activated in neurons that are destined to die. There are several potential routes through which NF-kappa B can act to induce neuronal death, including production of death proteins and an aborted attempt to reenter the cell cycle. NF-kappa B is only transiently activated in neurons that survive. Persistent NF-kappa B activation can be blocked by antioxidants, which suggests that the neuroprotective effect of antioxidants may be due to inhibiting activation of NF-kappa B.
This article was published in Free Radic Biol Med and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords