alexa Cerebral microbleeds: histopathological correlation of neuroimaging.


Journal of Neurology & Neurophysiology

Author(s): Shoamanesh A, Kwok CS, Benavente O

Abstract Share this page

Abstract BACKGROUND: In recent years, there has been a growing interest in cerebral microbleeds (CMBs) and their role in cerebrovascular disease. A few studies have investigated the histopathological correlation between CMBs and neuroimaging findings. We conducted a systematic review in an attempt to characterize the pathological and radiological correlation. METHODS: A systematic literature search was conducted for studies in which CMBs were characterized histopathologically and correlated with MRI findings. RESULTS: Five studies met the inclusion criteria, with a total of 18 patients. Hemosiderin deposition was reported in 42 CMBs (49\%), while 16 CMBs (19\%) were described as old hematomas which stained for iron, 13 (15\%) had no associated specific pathology, 11 (13\%) contained intact erythrocytes, 1 (1\%) was due to vascular pseudocalcification, 1 (1\%) was a microaneurysm and 1 (1\%) was a distended dissected vessel. Lipofibrohyalinosis was the most prominent associated vascular finding. Amyloid angiopathy was present primarily in patients with dementia. CONCLUSIONS: Although histopathological associations have been observed using MRI in patients with CMBs, the findings have yet to be validated and further research is warranted. Copyright © 2011 S. Karger AG, Basel. This article was published in Cerebrovasc Dis and referenced in Journal of Neurology & Neurophysiology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version