alexa Ceritinib: a new tyrosine kinase inhibitor for non-small-cell lung cancer.


Journal of Palliative Care & Medicine

Author(s): Cooper MR, Chim H, Chan H, Durand C

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Abstract OBJECTIVE: To review ceritinib for the treatment of anaplastic lymphoma kinase (ALK)-positive metastatic non-small-cell lung cancer (NSCLC). DATA SOURCES: Literature searches were conducted in PubMed, EMBASE (1974 to July week 5, 2014), and Google Scholar using the terms ceritinib, LDK378, and non-small-cell lung cancer. STUDY SELECTION AND DATA EXTRACTION: One phase 1 trial and 2 abstracts were identified. DATA SYNTHESIS: Ceritinib is approved for the treatment of ALK-positive metastatic NSCLC in patients who are intolerant to or have progressed despite therapy with crizotinib. In the phase 1 clinical trial, the maximum tolerated dose was determined to be 750 mg once daily. The overall response rate (ORR) was 58\% (95\% CI = 48-67) in patients who received ≥400 mg daily (n = 114). In this group, the ORR was 56\% (95\% CI = 41-67) and 62\% (95\% CI = 44-78) among crizotinib-exposed and -naïve patients, respectively. The ORR was 59\% (95\% CI = 47-70) in patients who received 750 mg daily (n = 78). The ORR was 56\% (95\% CI = 41-70) in crizotinib-treated patients and 64\% (95\% CI = 44-81) in crizotinib-naïve patients, respectively, in this subset. The median duration of response was 8.2 months. Median progression-free survival was 7.0 months. The most common adverse reactions included diarrhea, nausea, vomiting, abdominal pain, anorexia, constipation, fatigue, and elevated transaminases. CONCLUSIONS: Ceritinib has activity in crizotinib-resistant and crizotinib-naïve patients and appears to be a viable alternative for ALK-positive NSCLC. Long-term data are needed to further define the role of ceritinib in the treatment of NSCLC. © The Author(s) 2014. This article was published in Ann Pharmacother and referenced in Journal of Palliative Care & Medicine

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