alexa CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): Conley YP, Jakobsdottir J, Mah T, Weeks DE, Klein R

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Age-related maculopathy (ARM) is an important cause of visual impairment in the elderly population. It is of crucial importance to identify genetic factors and their interactions with environmental exposures for this disorder. This study was aimed at investigating the CFH, ELOVL4, PLEKHA1 and LOC387715 genes in independent cohorts collected using different ascertainment schemes. The study used a case-control design with subjects originally recruited through the Cardiovascular Health Study (CHS) and the Age-Related Eye Disease Study (AREDS). CFH was significantly associated with ARM in both cohorts (P

This article was published in Format: Abstract Send to Hum Mol Genet and referenced in Journal of Clinical Research & Bioethics

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