alexa c-Fos immunoreactivity in selected brain regions of rats after heat exposure and pyrogen administration.


Journal of Alzheimers Disease & Parkinsonism

Author(s): du Plessis I, Mitchell D, Niesler C, Laburn HP

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Abstract We determined c-Fos immunoreactivity (Fos-IR) in selected hypothalamic nuclei, the organum vasculosum of the laminae terminals (OVLT) and somatosensory cortex of rats after hyperthermia induced by exogenous heat exposure, Gram-negative or Gram-positive pyrogen administration. The magnitude of Fos-IR was similar in thermoregulatory hypothalamic nuclei of rats after heat exposure or lipopolysaccharide (LPS) injection, despite the different origins of the hyperthermias. Heat-induced hyperthermia was associated with increased Fos-IR in the somatosensory cortex. LPS, but not heat exposure or injection of killed Staphylococcus aureus cells activated OVLT neurons. The OVLT may thus not be a port of entry for humoral mediators of Gram-positive bacterial fevers. This article was published in Brain Res and referenced in Journal of Alzheimers Disease & Parkinsonism

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