Author(s): Archana Singh Sikarwar, Harsh Vardhan Batra
Klebsiella pneumoniae has been associated with different types of infections and one of the important aspects of Klebsiella associated infection is the emergence of multi-drug resistant strains particularly those involved in nosocomial diseases. For our studies we have collected fifty – nine clinical isolates, from different places of India as this study was conducted in India. Morphologically resembled Klebsiella were recovered from respiratory, UTI and pus cases. Out of fifty- nine clinical isolates, twenty were found positive for K.pneumoniae at biochemical characterization. These clinical isolates of K.pneumoniae were further tested for antimicrobial sensitivity and most of them were found to be multidrug resistant. All confirmed K.pneumoniae isolates were resistant to carbenicillin and one among them recovered from sputum sample of a pneumonic patient was resistant to all the antimicrobial agents tested except exhibiting a partial susceptibility to amikacin. Klebsiella pneumoniae strains from clinical cases in our study were found highly susceptible to quinolones, aminoglycoside, amykacin and gentamycin. At the same time over 60% strains were resistant to chloramphenicol and tetracycline. We also found that 28 to 76% of them were resistant to cephalosporins (ceftizoxime and cefotaxime).