alexa Challenges for the oral delivery of macromolecules.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Goldberg M, GomezOrellana I

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Abstract The rapid integration of new technologies by the pharmaceutical industry has resulted in numerous breakthroughs in the discovery, development and manufacturing of pharmaceutical products. In particular, the commercial-scale production of high-purity recombinant proteins has resulted in important additions to treatment options for many large therapeutic areas. In addition to proteins, other macromolecules, such as the animal-derived mucopolysaccharide heparins, have also seen dramatic growth as injectable pharmaceutical products. To date, macromolecules have been limited as therapeutics by the fact that they cannot be orally delivered. This article will address the current status and future possibilities of oral macromolecular drug delivery. This article was published in Nat Rev Drug Discov and referenced in Journal of Nanomedicine & Nanotechnology

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