Author(s): Mitj O, Hays R, Lelngei F, Laban N, Ipai A,
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Abstract A global resurgence of yaws in developing countries highlights the need for reliable diagnostic criteria for this neglected infection. We conducted a clinical and serologic survey of 233 children less than 15 years of age who had clinically suspected yaws. A total of 138 (59\%) cases were confirmed serologically, and 10 of 12 primary stage cases showed positive results for Treponema pallidum by a polymerase chain reaction assay that has not yet been validated for identification of yaws. A high proportion of cases (46\%) were in the secondary stage; 92\% of them had osteoarticular involvement, and only 24\% had a Venereal Disease Research Laboratory titer greater than 1:32.
This article was published in Am J Trop Med Hyg
and referenced in Journal of Antivirals & Antiretrovirals