Author(s): Hoa NB, Lauritsen JM, Rieder HL, Hoa NB, Lauritsen JM, Rieder HL, Hoa NB, Lauritsen JM, Rieder HL, Hoa NB, Lauritsen JM, Rieder HL
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Abstract SETTING: National Tuberculosis Programme, Viet Nam, 2008. OBJECTIVE: To assess the relationship between changes in body weight and tuberculosis (TB) treatment outcome. METHODS: All treatment cards of patients from a sample of 30 randomly selected treatment units in the country were analysed. RESULTS: Of 2609 patients, 2506 (96.1\%) had a successful treatment outcome. The median body weight of all patients at diagnosis was 46.0 kg (25th and 75th percentiles 41-51). New sputum smear-positive TB patients with a successful treatment outcome gained an average of 2.6 kg during treatment. Patients with weight loss during the first 2 months of treatment were more likely to have an unsuccessful outcome than patients without (OR 4.9, 95\%CI 3.0-7.9). Patients weighing <40 kg at treatment start who gained more than 5\% of their body weight after 2 months of treatment had a significantly smaller risk of an unsuccessful treatment outcome than patients who did not (OR 0.2, 95\%CI 0.05-0.96). CONCLUSIONS: Patients failing to gain weight or losing weight, particularly during the first 2 months of treatment, require particular attention, as they appear to be at an increased risk of unsuccessful treatment outcome.
This article was published in Int J Tuberc Lung Dis
and referenced in Journal of Nutritional Disorders & Therapy