alexa Changes in cardiovagal baroreflex sensitivity are related to increased ventricular mass in patients with liver cirrhosis.


Journal of Anesthesia & Clinical Research

Author(s): Song JG, Kim YK, Shin WJ, Hwang GS

Abstract Share this page

Abstract BACKGROUND: Morphological and functional cardiac modifications attributable to neurohumoral activation and hyperdynamic circulation have been found in patients with liver cirrhosis (LC). Cardiovagal baroreflex sensitivity (BRS) has been shown to inversely correlate with left ventricular (LV) morphology. It was hypothesized that, in patients with cirrhotic cardiomyopathy, reduced BRS is associated with myocardial remodeling and increased LV mass index (LVMI). METHODS AND RESULTS: Eighty-two LC patients scheduled to undergo liver transplantation were evaluated. Spectral analysis was done of beat-by-beat blood pressure and heart rate (HR) time series and BRS was derived from their cross-spectral gain. Echocardiography before liver transplantation was used to evaluate heart morphology and function. BRS was inversely correlated with LV wall thickness (P=0.038), end-diastolic interventricular septum thickness (P=0.048), LVMI (P=0.005) and HR (P<0.001). On multivariate stepwise linear analysis LVMI and HR were independently associated with BRS. On tertile analysis of LVMI, compared with the lowest tertile of LVMI (75±11 g/m(2)), the highest tertile (118±13 g/m(2)) showed significantly impaired BRS (4.6±2.3 vs. 6.4±3.1 ms/mmHg, P=0.012). CONCLUSIONS: Reduced cardiovagal BRS is associated with increased LV mass in patients with LC, suggesting a relationship between cardiovagal BRS control of HR and cardiac end-organ damage in patients with cirrhotic cardiomyopathy.
This article was published in Circ J and referenced in Journal of Anesthesia & Clinical Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version