alexa Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer.
Medicine

Medicine

Journal of Gerontology & Geriatric Research

Author(s): Smith MR

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Abstract OBJECTIVES: To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer. METHODS: In a multicenter study, men with Stage M0 prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonadotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months. RESULTS: Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7\% +/- 3.0\% (P <0.001). Weight increased by 1.8\% +/- 0.5\% (P <0.001). The percentage fat mass increased by 11.0\% +/- 1.7\%, and the percentage lean mass decreased by 3.8\% +/- 0.6\% (P <0.001 for each comparison). CONCLUSIONS: Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer. This article was published in Urology and referenced in Journal of Gerontology & Geriatric Research

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