alexa Changing to NIPT as a first-tier screening test and future perspectives: opinions of health professionals.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Tamminga S, van Schendel RV, , Rommers W, Bilardo CM,

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Abstract OBJECTIVE: The aim of this study was to investigate health professionals' opinions toward offering noninvasive prenatal testing (NIPT) as first-tier screening test regardless of pregnant women's risk, and toward a potential broader range of disorders. METHODS: A questionnaire completed by obstetric health professionals (n = 240) after an in-service NIPT training in the West and North of the Netherlands. RESULTS: The majority (72\%) of respondents favored replacing first-trimester combined test (FCT) by NIPT, although 43\% preferred to maintain nuchal translucency measurement. Many respondents believed that replacing FCT by NIPT would only have advantages (57\%), would lead to more pregnant women opting for prenatal testing (69\%), and would simplify counseling (47\%). Differences in attitudes toward counseling between health professionals were observed. When considering NIPT to screen for broader range of disorders, the majority (92\%) thought that this should include disorders characterized by neonatal death, whereas 52\% of the respondents favored testing for fetomaternal risk factors. Overall, 46\% thought screening should be offered as a fixed list of disorders. CONCLUSION: Most health professionals favor NIPT instead of FCT but prefer to maintain nuchal translucency measurement. If NIPT becomes available as a first-tier screening test, attention remains necessary to ensure that pregnant women make well-informed decisions in line with the aim of prenatal screening. © 2015 John Wiley & Sons, Ltd. This article was published in Prenat Diagn and referenced in Journal of Genetic Syndromes & Gene Therapy

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