alexa Characteristics of intracranial aneurysms and subarachnoid haemorrhage in patients with polycystic kidney disease.
Biochemistry

Biochemistry

Biochemistry & Physiology: Open Access

Author(s): Gieteling EW, Rinkel GJ

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Abstract BACKGROUND AND PURPOSE: Subarachnoid haemorrhage is a common cause of death in patients with autosomal dominant polycystic kidney disease (ADPKD), but little is known about specific characteristics of subarachnoid haemorrhage and intracranial aneurysms in this group of patients. We performed a systematic review on site, size and number of aneurysms, age at time of rupture, gender, and family history in patients with ADPKD and intracranial aneurysms. We also studied the frequency of ADPKD in patients with subarachnoid haemorrhage treated in our hospital. METHODS: We performed a MEDLINE search and checked the reference lists of all relevant publications to identify all articles published from 1980 to 2000 on intracranial aneurysms or subarachnoid haemorrhage in ADPKD. We studied our database of patients with subarachnoid haemorrhage treated between 1978 and 1999 for the presence of ADPKD. RESULTS: We included 53 articles on 369 ADPKD patients (139 [54 \%] women) with 462 intracranial aneurysms. Of the 273 aneurysms with specified locations 105 (38 \%) were located on the middle cerebral artery in and on the anterior communicating artery in 83 patients (30 \%). In 253 patients with data about relatives, the family history was positive for intracranial aneurysms or subarachnoid haemorrhage in 102 (40 \%). The average age at which subarachnoid haemorrhage had occurred in 258 was 41 years; of 158 in whom the gender was given; 96 (52 \%) were women. Of the 160 patients with data on outcome, 69 (43 \%) had died as the result of the subarachnoid haemorrhage. Of the 1147 patients treated for aneurysmal subarachnoid haemorrhage in our institution (mean age 53 years; 65.5 \% women), 5 (0.44 \%) had ADPKD. CONCLUSIONS: Compared with data on patients without ADPKD, subarachnoid haemorrhage in patients with ADPKD occurs not only often in a familial setting of subarachnoid haemorrhage, but also at an earlier age and more often in men. In patients with ADPKD, the most frequent site of aneurysms is the middle cerebral artery. The proportion of patients with ADPKD among all patients with subarachnoid haemorrhage is very small. This article was published in J Neurol and referenced in Biochemistry & Physiology: Open Access

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