alexa Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Down Syndrome & Chromosome Abnormalities

Author(s): Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC

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Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

This article was published in Science and referenced in Journal of Down Syndrome & Chromosome Abnormalities

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