alexa Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary.


Journal of Antivirals & Antiretrovirals

Author(s): Reuter G, Fodor D, Forgch P, Ktai A, Szucs G

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Abstract BACKGROUND: Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raising the possibility that HEV infection is also a zoonosis. OBJECTIVES/STUDY DESIGN: Molecular detection and epidemiology of HEV in humans (South-East Hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by ELISA and RT-PCR. RESULTS: Between 2001 and 2006, a total of 116 (9.6\%) of 1203 human sera were positive by HEV IgM ELISA and 13 (24.5\%) of 53 samples were also confirmed by RT-PCR and sequencing. Forty-two (27.3\%) of 154, 11 (34.4\%) of 32 and 9 (12.2\%) of 74 samples were RT-PCR-positive from swine (feces: 22.7\%; liver: 30.8\%), roe-deer (liver) and wild boar (liver), respectively. Except for an imported infection caused by genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: 1, wild boar: 2) belong to genotype 3 HEV. Genetically identical strains were detected in human and roe-deer and in 2 other human clusters. CONCLUSIONS: HEV is an endemic agent in Hungary. Consumption of raw or undercooked meat-products is one of the possible sources of the indigenous HEV infections. Cross-species infection with genotype 3 HEV potentially involves a food-borne transmission route in Hungary. This article was published in J Clin Virol and referenced in Journal of Antivirals & Antiretrovirals

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