alexa Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein.


Journal of Antivirals & Antiretrovirals

Author(s): Feldmann H, Nichol ST, Klenk HD, Peters CJ, Sanchez A

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Abstract Eight different filovirus isolates, representing major episodes of filovirus hemorrhagic disease, were propagated for structural and antigenetic analyses of their glycoprotein (GP). Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. These data, together with prior findings, indicate that the genus Filovirus can be divided into a MBG group and EBO group. This article was published in Virology and referenced in Journal of Antivirals & Antiretrovirals

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