alexa Characterization of rabies virus from a human case in Nepal


Journal of Vaccines & Vaccination

Author(s): Pant GR, Horton DL, Dahal M, Rai JN, Ide S

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Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs (Canis familiaris). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the 'arctic-like' lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo.

This article was published in Arch Virol and referenced in Journal of Vaccines & Vaccination

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