alexa Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C,

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Abstract Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53. 2010 Elsevier Inc. All rights reserved. This article was published in Cancer Cell and referenced in Journal of Antivirals & Antiretrovirals

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