Author(s): Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C,
Abstract Share this page
Abstract Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53. 2010 Elsevier Inc. All rights reserved.
This article was published in Cancer Cell
and referenced in Journal of Antivirals & Antiretrovirals