Author(s): Herwig J, Egner E, Buddecke E
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Abstract Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72\% water, 0.12\% DNA, 22\% collagen, and 0.8\% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40\% chondroitin 6-sulphate, 10-20\% chondroitin 4-sulphate, 20-30\% dermatan sulphate, and 15\% keratan sulphate. The water content increased with increasing degeneration, whereas the collagen and glycosaminoglycan contents decreased with relative increase of chondroitin 6-sulphate.
This article was published in Ann Rheum Dis
and referenced in Journal of Thermodynamics & Catalysis