Author(s): Yana Hristova, Velizar Gochev, Juergen Wanner, Leopold Jirovetz, Erich Schmidt
The essential oil of Salvia sclarea L., growing in Bulgaria, was analyzed by gas chromatography – mass spectrometry. A total of 52 different compounds were identified, representing 98.25 % of total oil content. Linalyl acetate (56.88%) and linalool (20.75 %) were determined as major essential oil constituents, followed by germacrene D (5.08%) and β - cariophyllene (3.41%). Antifungal activities of clary sage essential oil and major compounds linalyl acetate and linalool against 30 clinical isolates, belonging to species Candida albicans , Candida tropicalis , Candida krusei, Candida glabrata and Candida parapsilosis were evaluated. Essential oil characterized with stronger anticandidial activity in comparison with pure compounds.