alexa Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity.


Natural Products Chemistry & Research

Author(s): Sun YN, Li W, Kim JH, Yan XT, Kim JE,

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Abstract Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type. This article was published in Arch Pharm Res and referenced in Natural Products Chemistry & Research

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