alexa Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D, , Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D, , Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D, , Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D,

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Abstract Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagonists in vitro and had antitumor efficacy in a prostate cancer xenograft model which, on a molar basis, far exceeded the activity of the parent small molecule. This article was published in Bioorg Med Chem Lett and referenced in Immunotherapy: Open Access

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