alexa Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer.


Autism-Open Access

Author(s): Abraham RT

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Abstract Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Cancer Cell and referenced in Autism-Open Access

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