alexa Childhood microscopic polyangiitis associated with MPO-ANCA.
Cardiology

Cardiology

Journal of Vasculitis

Author(s): PecoAntic A, BonaciNikolic B, BastaJovanovic G, Kostic M, MarkovicLipkovski J,

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Abstract We reviewed the clinical, histological and serological parameters of microscopic polyangiitis (MPA) associated with antineutrophil cytoplasmic antibodies (ANCA) specific to myeloperoxidase (MPO). Six girls and one boy aged 12.0+/-2.6 years (7-15 years) met the following inclusion criteria: (1) clinical manifestations of systemic small vessel involvement; (2) histological demonstration of pauci-immune necrotizing glomerulonephritis; and (3) serological findings of increased concentration of MPO-ANCA by ELISA test. The main clinical manifestations were: influenza-like symptoms (100\%), hematuria/proteinuria (100\%), purpura (100\%), pulmonary-renal syndrome (57\%), acute renal failure (ARF) (29\%), ischemic cerebral insults (29\%), and necrotizing vasculitis of the skin (29\%). All patients underwent renal biopsy examined by immunohistochemistry with expression of alpha-smooth muscle actin (alpha SMA) in glomerular and interstitial spaces. Patients were followed from 6 months to 5.5 years (35.4+/- 23.2 months). None of the patients died. Two of seven children who had ARF progressed to end stage renal disease; one developed chronic renal failure, and four normalized renal function. ARF and central nervous system involvement at presentation were parameters of poor renal outcome. A high score of fibro-cellular glomerular crescents was associated with worse prognosis. Early treatment enables a favorable prognosis of MPO-ANCA-associated MPA in children. This article was published in Pediatr Nephrol and referenced in Journal of Vasculitis

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